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Updated: Oct 22, 2025
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
[Multiple skull base defects: features of pathogenesis, diagnosis and treatment]
E V Shelesko1, N A Chernikova1, A D Kravchuk1
1Burdenko Neurosurgical Center, Moscow, Russia.
Objective:
To determine the risk factors of multiple skull base defects, as well as features of diagnosis and treatment of this pathology.
Material And Methods:
A retrospective analysis included 39 patients who underwent surgery for nasal CSF leakage at the Burdenko Neurosurgical Center in 2000-2019. The study recruited patients with multiple simultant skull base defects.
Results:
Traumatic defects were observed in 23 (59%) patients, spontaneous defects - in 16 (41%) cases. All patients underwent endoscopic endonasal closure of skull base defects with autografts.
Conclusion:
Multiple defects are more common in severe traumatic brain injury. The main risk factors of multiple spontaneous defects are female sex and overweight. Adequate diagnosis implies high-resolution CT (slice width 0.5-1 mm), as well as intraoperative control of all suspicious and «weak» areas. Endoscopic endonasal technique is effective and safe for multiple skull base defects (efficiency 97%).
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