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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Related Experiment Video

Updated: Oct 22, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Frailty, aging, and periodontal disease: Basic biologic considerations.

Daniel Clark1, Eftychia Kotronia2, Sheena E Ramsay2

  • 1Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.

Periodontology 2000
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Summary

Aging increases the risk of periodontal disease and frailty, common conditions in older adults. These conditions likely influence each other bidirectionally, potentially through inflammation.

Keywords:
agingcell biologyfrailtyinflammationperiodontal disease

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Area of Science:

  • Gerontology
  • Oral Health
  • Immunology

Background:

  • Aging is linked to increased disease prevalence, including periodontal disease and frailty.
  • Frailty is a condition in older adults increasing adverse health outcome risks.
  • Periodontal disease and frailty are common chronic conditions in older populations with shared risk factors.

Purpose of the Study:

  • To explore the bidirectional relationship between periodontal disease and frailty in older adults.
  • To identify underlying mechanisms connecting periodontal disease and frailty, focusing on inflammation and immune dysregulation.

Main Methods:

  • Review of existing literature on aging, periodontal disease, frailty, and inflammation.
  • Analysis of shared risk factors and pathophysiologic pathways.
  • Exploration of immune cell involvement in age-related inflammatory dysregulation.

Main Results:

  • A likely bidirectional relationship exists between periodontal disease and frailty.
  • Comorbidities, functional decline, and self-care deficits in frail individuals may link the two conditions.
  • Both conditions are associated with inflammatory dysregulation and age-related pathophysiologic changes.

Conclusions:

  • Understanding the interplay between periodontal disease and frailty is crucial for geriatric health.
  • Investigating age-related immune changes could reveal therapeutic targets for managing both conditions.
  • Targeting inflammatory pathways may improve outcomes for frail older adults with periodontal disease.