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Predictors of functioning and clinical outcomes in inpatient with schizophrenia on clozapine augmented with
Hindol Mukherjee1, Vladimir Sazhin2
1Forensic Psychiatry Advanced Trainee, Cumberland Hospital (Western Sydney Local Health District) and Justice and Forensic Mental Health Network, NSW, Australia.
Objective:
We aimed at exploring predictors of improvement in clinical and functional outcomes of patients on clozapine with chronic treatment-resistant schizophrenia admitted into rehabilitation wards.
Method:
In a cross-sectional study of 62 patients on clozapine augmented with oral and parenteral antipsychotics, predictors of HoNOS (Health of the Nation Outcome Scales) scores were analysed using ordinal logistic regression.
Result:
Augmentation with parenteral antipsychotics was associated with lower psychotic symptom scores (OR 0.38 [95%CI 0.15, 0.99]) and activity of daily living scores (OR 0.36 [95%CI, 0.13, 0.96]) compared with oral antipsychotics. Increased age was a predictor of behavioural disturbances, physical illness and cognitive problems for all clozapine patients, and female gender was associated with the increase in depression scores.
Conclusion:
The addition of parental antipsychotics to clozapine in patients with treatment-resistant schizophrenia might have potential benefits for clinical and functional outcomes and needs a further investigation.
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