Related Experiment Video
Updated: Oct 22, 2025

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
Clustering Hidden Markov Models With Variational Bayesian Hierarchical EM
Abstract:
The hidden Markov model (HMM) is a broadly applied generative model for representing time-series data, and clustering HMMs attract increased interest from machine learning researchers. However, the number of clusters ( K ) and the number of hidden states ( S ) for cluster centers are still difficult to determine. In this article, we propose a novel HMM-based clustering algorithm, the variational Bayesian hierarchical EM algorithm, which clusters HMMs through their densities and priors and simultaneously learns posteriors for the novel HMM cluster centers that compactly represent the structure of each cluster. The numbers K and S are automatically determined in two ways. First, we place a prior on the pair (K,S) and approximate their posterior probabilities, from which the values with the maximum posterior are selected. Second, some clusters and states are pruned out implicitly when no data samples are assigned to them, thereby leading to automatic selection of the model complexity. Experiments on synthetic and real data demonstrate that our algorithm performs better than using model selection techniques with maximum likelihood estimation.
Related Concept Videos
Cluster Sampling Method
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Multicompartment Models: Overview
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Variability: Analysis
The range is a simple measure of variability, indicating the difference between the highest and...
Vesicular Tubular Clusters
With the help of motor proteins such...

