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Updated: Oct 22, 2025

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
Illuminating the Fc dependence of SARS-CoV-2 neutralization
Joseph C González1, Taia T Wang2
1Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA; Immunology Interdepartmental Program, Stanford University, Stanford, CA, USA.
Abstract:
Monoclonal antibodies show efficacy in treating COVID-19, but the functional requirements for protection are unclear. In this issue of Immunity, Ullah et al. (2021) develop a stable SARS-CoV-2 reporter virus and use bioluminescence imaging to longitudinally monitor infection and assess neutralizing monoclonal antibody interventions in mice. They find that antibody-mediated protection depends on the Fc domain and Fc-gamma receptor-expressing immune cells.

