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Updated: Oct 22, 2025

Author Spotlight: Decoding Mitochondrial Aging
Published on: June 30, 2023
Mitochondrial links between brain aging and Alzheimer's disease
Heather M Wilkins1,2,3, Russell H Swerdlow4,5,6,7
1University of Kansas Alzheimer's Disease Research Center, Kansas City, KS, USA.
Abstract:
Advancing age is a major risk factor for Alzheimer's disease (AD). This raises the question of whether AD biology mechanistically diverges from aging biology or alternatively represents exaggerated aging. Correlative and modeling studies can inform this question, but without a firm grasp of what drives aging and AD it is difficult to definitively resolve this quandary. This review speculates over the relevance of a particular hallmark of aging, mitochondrial function, to AD, and further provides background information that is pertinent to and provides perspective on this speculation.
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