Related Experiment Video

Updated: Aug 11, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.5K

Neonatal stroke in premature neonates

S J Steggerda1, L S de Vries2

  • 1Department of Neonatology, Leiden University Medical Center, PO Box 85090, Utrecht 3508 AB, the Netherlands.

Seminars in Perinatology
|September 1, 2021
PubMed

Insights

Neonatal stroke, including perinatal arterial ischemic stroke (PAIS) and cerebral sinovenous thrombosis (CSVT), is under-represented in preterm infant neuro-imaging research. This review focuses on neuro-imaging findings for stroke in preterm infants.

Area of Science:

  • Neonatal neurology
  • Pediatric neuroimaging
  • Perinatal medicine

Background:

  • Neuro-imaging studies in preterm infants commonly focus on germinal matrix-intraventricular hemorrhage (GMH-IVH) and white matter injury.
  • Data on perinatal arterial ischemic stroke (PAIS) and cerebral sinovenous thrombosis (CSVT) in preterm infants are notably limited.
  • Existing large cohort studies on preterm infant neuro-imaging often do not report on neonatal stroke, and PAIS research frequently excludes preterm populations.

Purpose of the Study:

  • To provide an updated review of neonatal stroke in preterm infants.
  • To specifically focus on the neuro-imaging findings associated with stroke in this population.

Main Methods:

  • Literature review of neuro-imaging studies concerning preterm infants.
  • Analysis of data focusing on perinatal arterial ischemic stroke (PAIS) and cerebral sinovenous thrombosis (CSVT).
  • Synthesis of findings from cranial ultrasound (cUS) and term equivalent age MRI (TEA-MRI) studies.

Main Results:

  • Limited data exists on PAIS and CSVT in preterm infants compared to other brain lesions.
  • Many neuro-imaging studies on preterm infants overlook or exclude neonatal stroke.
  • PAIS research predominantly focuses on term infants, excluding preterm cases.

Conclusions:

  • There is a significant gap in the literature regarding neuro-imaging of neonatal stroke in preterm infants.
  • Further research is needed to accurately characterize and diagnose PAIS and CSVT in the preterm population using neuro-imaging.
  • This review highlights the need for increased attention to neonatal stroke in preterm infant neuro-imaging studies.

Keywords:
infarctpretermsinovenous thrombosisstroke

More Related Videos

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

10.7K
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

872

Related Concept Videos

Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...