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Related Experiment Videos

Drug-induced scleroderma-like lesion.

Yasuhito Hamaguchi1

  • 1Department of Molecular Pathology of Skin, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Allergology International : Official Journal of the Japanese Society of Allergology
|September 1, 2021
PubMed
Summary
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Drug-induced scleroderma-like lesions mimic systemic sclerosis but lack systemic features. Early recognition and drug discontinuation are key, though some cases may require systemic therapy.

Area of Science:

  • Dermatology
  • Pharmacology
  • Pathology

Background:

  • Drug-induced scleroderma-like lesion presents as skin sclerosis mimicking systemic sclerosis or morphea.
  • Clinical features include scleroderma-like lesions and morphea-like plaques.
  • Diverse medications, including chemotherapy and immune checkpoint inhibitors, are implicated.

Purpose of the Study:

  • To review the clinical characteristics, causative agents, and management of drug-induced scleroderma-like lesions.
  • To differentiate drug-induced scleroderma-like lesions from systemic sclerosis.
  • To highlight the importance of considering drug induction in patients with sclerotic skin lesions.

Main Methods:

  • Literature review of reported cases of drug-induced scleroderma-like lesions.
Keywords:
DrugFibrosisMorpheaSclerodermaSkin sclerosis

Related Experiment Videos

  • Comparison of clinical and laboratory findings with systemic sclerosis.
  • Analysis of treatment outcomes and patient responses.

    • Main Results:

    • Drug-induced scleroderma-like lesions typically lack systemic manifestations like Raynaud's phenomenon or organ involvement seen in systemic sclerosis.
    • Recent increases in cases linked to chemotherapy and immune checkpoint inhibitors.
    • Improvement after drug withdrawal varies; severe cases may need systemic therapy (e.g., steroids).

    Conclusions:

    • Drug-induced scleroderma-like lesion is a distinct entity that requires careful diagnosis.
    • Identifying the causative drug and discontinuing it is crucial for management.
    • Awareness of drug-induced etiology is essential for effective patient care.