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Lorlatinib-induced visual and auditory hallucinations: A case report
Jun Hakamata1, Hideo Nakada2, Hiroshi Muramatsu1
1Department of Pharmacy Keio University Hospital Tokyo Japan.
Lorlatinib may cause visual and auditory hallucinations. These hallucinations can continue even after stopping lorlatinib treatment in some patients.
Area of Science:
- Neuroscience
- Oncology
Background:
- Lorlatinib is an FDA-approved anaplastic lymphoma kinase (ALK) and ROS1 tyrosine kinase inhibitor.
- It is used to treat certain types of non-small cell lung cancer (NSCLC).
Observation:
- Patients treated with lorlatinib may experience hallucinations.
- These hallucinations can be visual or auditory.
Findings:
- Hallucinations are a potential side effect of lorlatinib therapy.
- In some cases, hallucinations may persist even after the discontinuation of lorlatinib.
Implications:
- Clinicians should monitor patients for hallucinations during and after lorlatinib treatment.
- Awareness of persistent hallucinations is crucial for patient management and supportive care.
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