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Cardio-Oncology: Understanding the Intersections Between Cardiac Metabolism and Cancer Biology

Anja Karlstaedt1,2, Matthew Barrett3, Ray Hu4

  • 1Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

JACC. Basic to Translational Science
|September 1, 2021
PubMed

Insights

Cancer survivors face increased long-term cardiovascular disease risk due to cancer therapeutics and cancer biology. Understanding metabolic interactions is key to developing new cardio-oncology treatments.

Area of Science:

  • Cardio-oncology
  • Cancer biology
  • Cardiovascular disease

Background:

  • Cancer patient survival rates have significantly improved.
  • Cancer survivors have a higher long-term risk of cardiovascular disease.
  • This risk stems from cancer therapeutics toxicity and cancer biology itself.

Purpose of the Study:

  • To review the metabolic interactions between cancer and the heart.
  • To identify potential therapeutic targets for cardio-oncology.
  • To discuss imaging techniques and future research directions.

Main Methods:

  • Review of current literature on cancer metabolism and cardiovascular effects.
  • Analysis of molecular mechanisms linking cancer and heart disease.
  • Overview of relevant imaging modalities.

Main Results:

  • Cancer and heart disease share complex metabolic pathways.
  • Metabolic dysregulation in cancer impacts cardiovascular health.
  • Targeting these metabolic interactions offers therapeutic potential.

Conclusions:

  • Cross-disciplinary efforts are essential to improve cardiovascular care for cancer patients and survivors.
  • Further research into metabolic interactions is crucial for advancing cardio-oncology.
  • Developing novel therapeutic targets can mitigate long-term cardiovascular risks.

Keywords:
99mTc-MIBI, 99mtechnetium-sestamibiCVD, cardiovascular diseaseD2-HG, D-2-hydroxyglutarateFAO, fatty acid oxidationFASN, fatty acid synthaseGLS, glutaminaseHF, heart failureIDH, isocitrate dehydrogenaseIGF, insulin-like growth factorMCT1, monocarboxylate transporter 1MRS, magnetic resonance spectroscopyPDH, pyruvate dehydrogenasePET, positron emission tomographyPI3K, insulin-activated phosphoinositide-3-kinasePTM, post-translational modificationSGLT2, sodium glucose co-transporter 2TRF, time-restricted feeding[18F]FDG, 2-deoxy-2-[fluorine-18]fluoro-D-glucosecancercardio-oncologyheart failuremetabolismoncometabolismα-KG, α-ketoglutarate

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