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Quetiapine-Induced Thyroid Dysfunction: A Systematic Review.

Mohamed Adil Shah Khoodoruth1, Ameen Khamis Abedalaziz Abdo1, Sami Ouanes1

  • 1Department of Psychiatry, Hamad Medical Corporation, Doha, Qatar.

Journal of Clinical Pharmacology
|September 1, 2021
PubMed
Summary
This summary is machine-generated.

Quetiapine treatment can cause thyroid abnormalities, primarily hypothyroidism. Further research is needed to understand the mechanisms and clinical factors influencing this association in patients.

Keywords:
adverse effectsantipsychotichypothyroidpsychopharmacologyquetiapineseroquelsystematic reviewthyroidthyroid gland

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Area of Science:

  • Pharmacology
  • Endocrinology
  • Psychiatry

Background:

  • Thyroid abnormalities are known side effects of quetiapine.
  • Changes in thyroid hormones can negatively impact mood in patients.
  • Limited understanding exists regarding clinical factors and mechanisms of quetiapine-induced thyroid issues.

Purpose of the Study:

  • To systematically review the literature on quetiapine-induced thyroid abnormalities.
  • To identify clinical factors and potential mechanisms involved.

Main Methods:

  • Systematic literature search of MEDLINE, PsycINFO, Google Scholar, and EMBASE.
  • Inclusion of case reports, case series, observational, and experimental studies.
  • Analysis of studies reporting biochemically confirmed thyroid abnormalities during quetiapine treatment.

Main Results:

  • A total of 32 studies were included (20 observational/experimental, 10 case reports, 1 case series).
  • Evidence across study designs suggests an association between quetiapine and hypothyroidism.
  • Limitations include study quality, lack of clear temporal relationship, and dose-response data.

Conclusions:

  • Quetiapine is associated with thyroid abnormalities, predominantly hypothyroidism.
  • Mechanisms may involve immunological and non-immunological pathways, but drug imputability is not always clear.
  • Large prospective studies are necessary to confirm the association and guide clinical management.