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Related Experiment Videos

Pressure changes in canine gall-bladder associated with emptying.

R T Mathie1, R O Plail, R S Stubbs

  • 1Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London.

The Journal of Physiology
|December 1, 1987
PubMed
Summary

Gallbladder emptying does not require a significant pressure increase. Physiological pressure changes are smaller than previously thought, suggesting older models may have introduced bile flow resistance.

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Area of Science:

  • Gastroenterology
  • Physiology

Background:

  • Previous assumptions suggested gallbladder emptying requires a 10-15 mmHg pressure rise and sphincter of Oddi relaxation.
  • This study re-examines gallbladder emptying mechanisms in dogs.

Purpose of the Study:

  • To investigate the physiological pressure changes in the gallbladder during emptying.
  • To determine if a significant rise in gallbladder pressure is a prerequisite for emptying.

Main Methods:

  • Continuous gallbladder pressure recording in six dogs with biliary fistulas.
  • Measurements were taken under fasting conditions, after feeding, and after intravenous infusion of cholecystokinin octapeptide (CCK-OP).
  • Gallbladder emptying was assessed by measuring bilirubin output from the fistula.

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Main Results:

  • Gallbladder pressure showed only a modest sustained rise of 2-3 mmHg after feeding and CCK-OP infusion.
  • A transient pressure rise of 3-10 mmHg was observed in some experiments.
  • Gallbladder emptying began before the peak pressure rise.

Conclusions:

  • A significant rise in gallbladder pressure is not necessary for gallbladder emptying.
  • Physiological pressure changes are smaller than previously reported, possibly due to artifact from older experimental models.
  • Gallbladder emptying occurs relatively quickly after food ingestion, highlighting the importance of cephalic and gastric phases.