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Cerium Containing Bioactive Glasses: A Review.
Alfonso Zambon1, Gianluca Malavasi1, Annalisa Pallini1
1Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, via Campi 103, 41125 Modena, Italy.
ACS Biomaterials Science & Engineering
|September 1, 2021
Summary
Cerium-doped bioactive glasses (Ce-BGs) show promise for biomedical uses, offering improved bioactivity, antibacterial, and antioxidant effects. This review details their development and therapeutic potential for surgical implants.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Biomedical Engineering
Background:
- Bioactive glasses (BGs) are engineered materials for medical implants.
- Doping BGs with therapeutic inorganic ions (TIIs) enhances performance and minimizes side effects.
- Cerium (Ce) is a rare earth element with catalytic properties gaining interest for BG applications.
Purpose of the Study:
- To review recent advancements in cerium-doped bioactive glasses (Ce-BGs) for biomedical applications.
- To evaluate the bioactivity, cytocompatibility, antibacterial, antioxidant, osteogenic, and angiogenic properties of Ce-BGs.
- To correlate these properties with Ce-BG composition and physicochemical parameters.
Main Methods:
- Literature review of recent studies on Ce-BGs.
- Analysis of various compositions and synthesis methods for Ce-BGs.
- Assessment of in vitro data on bioactivity, cellular interactions, and therapeutic effects.
Main Results:
- Ce-BGs exhibit diverse compositions, synthesis routes, and properties.
- Cerium doping influences bioactivity, cytocompatibility, and antibacterial efficacy.
- Ce-BGs demonstrate promising antioxidant, osteogenic, and angiogenic activities.
Conclusions:
- Ce-BGs represent a developing class of biomaterials with significant therapeutic potential.
- Composition and synthesis critically affect Ce-BG performance for biomedical applications.
- Further research is warranted to optimize Ce-BGs for specific clinical needs.
