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Depression and dry eye: a narrative review
Gabriela César Falcão Vieira1, Bruna Rachel de Oliveira Rodrigues2, Carlos Eduardo Ximenes da Cunha3
1Faculdade Nova Esperança - João Pessoa (PB), Brazil.
Revista Da Associacao Medica Brasileira (1992)
|September 1, 2021
Summary
Depression is linked to dry eye disease (DED), potentially worsening symptoms. Psychiatric medication side effects and chronic eye pain can exacerbate DED, highlighting the need for integrated treatment approaches.
Area of Science:
- Ophthalmology and Psychiatry
Background:
- Dry eye disease (DED) is a common, multifactorial ocular surface disorder.
- A notable association exists between DED and psychiatric disorders, particularly depression.
Purpose of the Study:
- To review the relationship between depression and DED.
- To explore the impact of psychotropic medications and depressive states on DED.
Main Methods:
- A narrative review of 13 articles published in the last decade.
- Analysis of studies focusing on the link between depression and dry eye.
Main Results:
- Depression is associated with the onset or exacerbation of DED, often linked to chronic eye pain.
- Selective serotonin reuptake inhibitors used for depression can induce ocular surface inflammation and cell apoptosis.
Conclusions:
- Integrated treatment strategies are needed for patients with both DED and psychiatric conditions.
- Further research should focus on optimizing psychiatric treatments to minimize ocular side effects and improve patient outcomes.
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