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Thyroid dysfunction in cerebral venous thrombosis: a retrospective cohort study.
Simon Fandler-Höfler1, Stefan Pilz2, Marion Ertler1
1Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036, Graz, Austria.
Journal of Neurology
|September 1, 2021
Summary
Thyroid dysfunction is common in cerebral venous thrombosis (CVT) patients, with nearly 18% affected. This suggests screening for thyroid issues in CVT cases may be beneficial.
Area of Science:
- Neurology
- Endocrinology
- Thrombosis Research
Background:
- Cerebral venous thrombosis (CVT) is a complex condition with numerous risk factors.
- Previous links between thyroid dysfunction and CVT are primarily based on limited case reports.
- Systematic investigations into thyroid dysfunction prevalence in CVT patients are lacking.
Purpose of the Study:
- To determine the frequency of thyroid dysfunction in a large cohort of cerebral venous thrombosis (CVT) patients.
- To analyze the clinical characteristics associated with thyroid dysfunction in CVT.
Main Methods:
- Retrospective analysis of 107 patients with imaging-confirmed CVT between 2006 and 2020.
- Extraction of clinical data from electronic medical records.
- Measurement of Thyroid-Stimulating Hormone (TSH) at admission; free thyroid hormones and autoantibodies analyzed when available.
Main Results:
- Thyroid dysfunction was present in 17.8% of CVT patients.
- Newly diagnosed hyperthyroidism (Graves' disease) occurred in 1.9% without typical symptoms.
- Hypothyroidism was found in 15.9%, including newly diagnosed subclinical cases.
Conclusions:
- A significant prevalence of thyroid dysfunction was observed in CVT patients.
- The frequent co-occurrence suggests a potential link requiring further investigation.
- TSH screening is recommended for patients diagnosed with CVT.
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