Related Experiment Video
Updated: Oct 21, 2025

Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease
Published on: November 8, 2017
The association between cognitive impairment/dementia and albuminuria: a systematic review and meta-analysis
Hongqin Li1,2, Shuailin Zhao1, Ruiyu Wang1
1Department II of Urology, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China.
Background:
To identify the association between albuminuria and dementia or cognitive impairment.
Methods:
The literature search was performed to identify relevant scientific studies through August 2019, including PubMed/Medline and EMBASE. For inclusion, the studies had to fulfil the following criteria: population-based cohort, case-control or cross-sectional studies; quantifying an association of albuminuria with cognitive impairment or dementia; and reported odds ratio (OR), and the corresponding 95% confidential interval (95% CI). Random effects model was used to yield pooled estimates.
Results:
A total of 16 studies (11 cohort studies and five cross-sectional studies) were included in the meta-analyses. Based on the fully adjusted estimates, albuminuria was associated with a significant higher risk of cognitive impairment or dementia. Furthermore, the same trend existed for cognitive impairment and dementia, respectively. In addition, both of Alzheimer's diseases (AD) and vascular dementia (VaD) were significantly associated with albuminuria.
Conclusion:
Albuminuria was significantly associated with cognitive impairment and dementia. Corresponding to an earlier subclinical time-point in kidney disease progress, albuminuria may be a potential factor predicting the future occurrence of dementia.
Related Concept Videos
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Nephrotic Syndrome II : Assessment and Medical Management
Nephrotic Syndrome I : Introduction
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Chronic Kidney Disease III: Interprofessional Care

