Mild/Moderate Asthma Network in Italy (MANI): a long-term observational study

Area of Science:

• Respiratory Medicine
• Epidemiology
• Clinical Research

Background:

• Mild-to-moderate asthma affects millions in Italy, yet longitudinal data on its progression and treatment response are scarce.
• Existing research often lacks real-world, long-term observational data crucial for understanding disease evolution.
• There's a need to bridge the gap between clinical research findings and daily patient care for mild-to-moderate asthma.

Purpose of the Study:

• To prospectively observe and understand the epidemiological evolution of mild and moderate asthma in a large Italian cohort.
• To gather real-world data on treatment responses, disease progression, and patient-reported outcomes.
• To investigate environmental and lifestyle factors influencing asthma management and outcomes.

Main Methods:

• The Mild/Moderate Asthma Network of Italy (MANI) is a prospective, observational cohort study.
• It involves 20,000 patients with mild-to-moderate asthma across Italy.
• Data collection includes patient-reported outcomes, treatment patterns, and functional/inflammatory markers.

Main Results:

• The study is ongoing, with primary outcomes focused on prospective observation and epidemiological trends.
• Secondary outcomes will provide insights into treatment efficacy and disease burden over time.
• Results are expected to inform long-term disease management strategies.

Conclusions:

• The MANI study will generate crucial real-world evidence for mild-to-moderate asthma.
• Findings will enhance understanding of disease history, treatment transferability, and the impact of current strategies.
• This research aims to improve the management and outcomes for a significant asthma population.