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Conjunctival Autofluorescence and Cytological Changes in Pterygium
Sangeetha Vijayam S Pai1, Alisha Kishore1, Seema Sen2
1Cornea, Cataract & Refractive Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences; and.
Cornea
|September 1, 2021
Summary
Autofluorescence and squamous metaplasia in the conjunctiva are associated with pterygium severity. These findings help understand pterygium progression and related cellular changes.
Area of Science:
- Ophthalmology
- Cell Biology
Background:
- Pterygium is a common ocular condition.
- Understanding its pathogenesis involves identifying associated cellular changes.
Purpose of the Study:
- To investigate the presence and patterns of autofluorescence in pterygium.
- To correlate autofluorescence with cytological alterations in the conjunctiva.
Main Methods:
- Evaluated 86 patients with pterygium and 76 controls.
- Assessed pterygium grade, autofluorescence, and conjunctival cytology.
- Utilized ImageJ software for photographic analysis of pterygium progression.
Main Results:
- Autofluorescence was detected in 51% of pterygium cases, predominantly at the leading edge.
- Higher pterygium grades (3 and 2) showed significantly more autofluorescence.
- Squamous metaplasia was prevalent in grade 3 pterygia (45%) compared to grade 2 (11.8%).
Conclusions:
- Conjunctival autofluorescence and squamous metaplasia are linked to pterygium severity.
- These findings provide insights into pterygium development and associated cytological changes.
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