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Updated: Oct 21, 2025

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
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FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's

Robert Goold1, Joseph Hamilton1, Thomas Menneteau2

  • 1UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1N 3BG, UK.

Cell Reports
|September 1, 2021
PubMed

Keywords:
CAG instabilityDNA repairFAN1FAN1 nuclease activityGWASHuntington’s diseaseMLH1MSH3mismatch repairrepeat expansion

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