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Updated: Oct 21, 2025
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Prediction of Genetic Alterations in Oncogenic Signaling Pathways in Squamous Cell Carcinoma of the Head and Neck:
Linyong Wu1, Peng Lin1, Yujia Zhao1
1From the Department of Medical Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning.
Objective:
This study investigated the role of radiomics in evaluating the alterations of oncogenic signaling pathways in head and neck cancer.
Methods:
Radiomics features were extracted from 106 enhanced computed tomography images with head and neck squamous cell carcinoma. Support vector machine-recursive feature elimination was used for feature selection. Support vector machine algorithm was used to develop radiomics scores to predict genetic alterations in oncogenic signaling pathways. The performance was evaluated by the area under the curve (AUC) of the receiver operating characteristic curve.
Results:
The alterations of the Cell Cycle, HIPPO, NOTCH, PI3K, RTK RAS, and TP53 signaling pathways were predicted by radiomics scores. The AUC values of the training cohort were 0.94, 0.91, 0.94, 0.93, 0.87, and 0.93, respectively. The AUC values of the validation cohort were all greater than 0.7.
Conclusions:
Radiogenomics is a new method for noninvasive acquisition of tumor molecular information at the genetic level.
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