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Updated: Oct 21, 2025
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
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A data-driven methodology towards evaluating the potential of drug repurposing hypotheses
Lucía Prieto Santamaría1,2,3, Esther Ugarte Carro1, Marina Díaz Uzquiano1
1Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, 28660 Boadilla del Monte, Madrid, Spain.
Computational and Structural Biotechnology Journal
|September 2, 2021
Summary
Drug repurposing accelerates treatment discovery by reusing approved drugs for new uses. This study identifies significant differences in data associated with successful drug repurposing, aiding future hypothesis generation.
Area of Science:
- Biomedical Informatics
- Pharmacology
- Computational Biology
Background:
- Drug repurposing offers a cost-effective and faster alternative to traditional drug development.
- Computational methods leverage diverse biomedical data to identify new therapeutic indications for existing drugs.
Purpose of the Study:
- To present a novel methodology for evaluating potential drug repurposing candidates.
- To identify distinguishing features of successful drug repurposing cases using disease-gene and disease-phenotype associations.
Main Methods:
- Utilized the DISNET platform for data collection.
- Analyzed known drug repurposing case studies against non-repurposing biomedical data.
- Performed genetical, phenotypical, and categorization level analyses.
Main Results:
- Identified statistically significant differences between data associated with drug repurposing and unrelated data.
- Demonstrated distinct patterns in genetic, phenotypic, and categorical information for repurposed drugs.
Conclusions:
- The developed methodology can effectively differentiate repurposing-related data.
- Findings provide valuable insights for generating new drug repurposing hypotheses.
Keywords:
ACE, Angiotensin I Converting EnzymeAHR, Aryl Hydrocarbon ReceptorALK, Anaplastic Lymphoma KinaseAPI, Application Programming InterfaceCMap, Connectivity MapCOX-2, Cyclooxygenase 2CUI, Concept Unique IdentifierDISNET knowledge baseDR, Drug Repurposing or Drug RepositioningDRD3, Dopamine Receptor D3Data integrationDisease understandingDrug repositioningDrug repurposingDrug-disease validationESR1, Estrogen Receptor 1ESR2, Estrogen Receptor 2FCGR2A, Fc Fragment Of IgG Receptor IIaFCGR3A, Fc Fragment Of IgG Receptor IIIaFCGR3B, Fc Fragment Of IgG Receptor IIIbGDA, Gene Disease AssociationICD-10-CM, International Classification of Diseases, 10th revision, Clinical ModificationID, IdentifierKDR, Kinase insert Domain ReceptorLTα, Lymphotoxin alphaMeSH-PA, Medical Subject Headings – Pharmacological ActionND, New DiseaseNLM, National Library of MedicineOD, Original DiseasePTGS2, Prostaglandin-endoperoxidase synthase 2SM, Supplementary MaterialSRD5A1, Steroid 5 Alpha-Reductase 1SRD5A2, Steroid 5 Alpha-Reductase 2TNFα, Tumour Necrosis Factor alphaUMLS, Unified Medical Language SystemMore Related Videos
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