[Interactions between cells and biomaterials in tissue engineering: a review].

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Cell Biology

Background:

• Tissue engineering relies on seed cells, biomaterials, and growth factors.
• Biomaterials serve as scaffolds, mimicking the extracellular matrix to support cell viability and function.
• Material surface properties critically influence cell adhesion, proliferation, migration, and differentiation.

Purpose of the Study:

• To review the impact of surface modification molecules on cell phenotypes and functions.
• To highlight the importance of cell-material interactions in tissue engineering.
• To emphasize the role of surface modification in optimizing biomaterial performance.

Main Methods:

• Literature review of studies on surface modification in tissue engineering.
• Analysis of how material surface properties affect cellular behavior.
• Synthesis of findings on the relationship between surface molecules and cell responses.

Main Results:

• Surface modification molecules directly interact with cells, guiding their behavior.
• These interactions are pivotal for cell adhesion, proliferation, migration, and differentiation.
• Optimized surface modifications enhance cellular function and tissue regeneration efficacy.

Conclusions:

• Surface modification molecules are key determinants of cell phenotypes and functions in tissue engineering.
• Understanding cell-surface interactions is essential for designing advanced biomaterials.
• Targeted surface modifications hold significant promise for regenerative medicine.