Computerized Working Memory Training for Children With Neurofibromatosis Type 1 (NF1): A Pilot Study

Area of Science:

• Neuroscience
• Pediatric Psychology
• Cognitive Rehabilitation

Background:

• Neurofibromatosis type 1 (NF1) is associated with cognitive deficits, particularly in working memory (WM).
• Effective interventions for improving cognitive functions in children with NF1 are needed.

Purpose of the Study:

• To assess the feasibility and efficacy of CogmedRM, a home-based computerized working memory training program.
• To evaluate the impact of CogmedRM on attention and executive functioning in children with NF1.

Main Methods:

• A pre-post study design was employed.
• Twenty-seven children (aged 8-15) with NF1 and WM difficulties participated.
• Participants completed 9 weeks of CogmedRM training, with adherence and cognitive changes as primary outcomes.

Main Results:

• Participants completed an average of 19.7 out of 25 sessions, achieving a 69% adherence rate.
• Significant improvements were observed in short-term memory, attention, and executive functioning (P < .05).

Conclusions:

• Computerized, home-based working memory training is feasible for children with NF1.
• CogmedRM demonstrates efficacy in improving cognitive deficits in this population.