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Updated: Oct 21, 2025

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
Published on: February 9, 2022
Response of heart rate variability and cardiorespiratory phase synchronization to routine bronchodilator test in
Chih-Hsiang Tsou1, Lin-Sen Pon2, Jun-Zhi Liang3
1Division of Chest Medicine, Ren-Ai Branch, Taipei City Hospital, Taipei; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taiwan.
Abstract:
Heart rate variability (HRV) and cardiorespiratory phase synchronization (CRPS) were employed to study the cardio- and respiratory interactions in patients with asthma receiving inhalation of beta2-agonist (Berotec 200 mcg) for routine bronchodilator test. Both time- and frequency-domain parameters were used to analyze the HRV. A weighted G-index was introduced to study the quality of the CRPS. The HRV parameters, in both the time and frequency domains, exhibited significant changes pointing to a sympathetic activation of the autonomic balance immediately after the inhalation. On the other hand, the CRPS index barely changed throughout the entire process. This indicates that inhalation of beta2-agonist does not alter the CRPS appreciably, and that the CRPS, in contrast to HRV, is relatively stable in response to the inhalation of beta2-agonist in patients with asthma.
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