Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

3.3K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
3.3K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

2.2K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.2K
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

3.1K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The EDIcebreaker: a new educational inclusive tool.

Biology of reproduction·2026
Same author

Postpartum Uterine Involution in Cows: Quantitative Assessment of Structural Remodeling and Immune Cell Infiltration.

Animals : an open access journal from MDPI·2025
Same author

Hippo Signaling Is Essential for the Maintenance of Zona Glomerulosa Cell Fate in the Murine Adrenal Cortex.

Endocrinology·2025
Same author

Lats1 and Lats2 regulate YAP and TAZ activity to control the development of mouse Sertoli cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2024
Same author

Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex.

International journal of molecular sciences·2022
Same author

Effect of Inactivation of <i>Mst1</i> and <i>Mst2</i> in the Mouse Adrenal Cortex.

Journal of the Endocrine Society·2022

Related Experiment Video

Updated: Oct 21, 2025

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands
08:37

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

Published on: October 2, 2018

24.5K

Adrenal Cortex Development and Maintenance: Knowledge Acquired From Mouse Models.

Nour Abou Nader1, Alexandre Boyer1

  • 1Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Canada.

Endocrinology
|September 2, 2021
PubMed
Summary

The adrenal cortex develops through complex stages, with stem/progenitor cell activity being sex-specific for maintaining its structure and function throughout life. Transgenic mouse models reveal key molecular mechanisms underlying these processes.

Keywords:
adrenal cortexadrenal glanddevelopmentmaintenancesexual dimorphismsignaling pathwayszonation

More Related Videos

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

8.2K
Mouse Adrenal Chromaffin Cell Isolation
18:30

Mouse Adrenal Chromaffin Cell Isolation

Published on: January 5, 2007

17.5K

Related Experiment Videos

Last Updated: Oct 21, 2025

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands
08:37

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

Published on: October 2, 2018

24.5K
Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

8.2K
Mouse Adrenal Chromaffin Cell Isolation
18:30

Mouse Adrenal Chromaffin Cell Isolation

Published on: January 5, 2007

17.5K

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Molecular Biology

Background:

  • The adrenal cortex is vital for producing essential steroid hormones.
  • Its development involves intricate stages from a common primordium with gonads to a definitive structure.
  • Maintenance relies on stem/progenitor cells with sex-specific activities.

Purpose of the Study:

  • To elucidate the molecular mechanisms governing adrenal cortex development and maintenance.
  • To highlight advances in understanding stem/progenitor cell regulation in the adrenal cortex.
  • To investigate sex-specific differences in adrenal cortex zonation and regeneration.

Main Methods:

  • Utilizing transgenic mouse models to study adrenal cortex development.
  • Investigating the proliferation, migration, and differentiation of stem/progenitor cell populations.
  • Analyzing molecular pathways regulating adrenal cortex zonation and maintenance.

Main Results:

  • Adrenal cortex development involves distinct fetal and definitive stages.
  • Stem/progenitor cell populations are crucial for zonation and lifelong regeneration.
  • Molecular mechanisms controlling these processes exhibit sex-specific regulation.

Conclusions:

  • Understanding the molecular basis of adrenal cortex development is critical for endocrine health.
  • Transgenic mouse models provide powerful tools for dissecting complex biological processes.
  • Sex-specific regulation of stem/progenitor cells is a key feature of adrenal cortex maintenance.