Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

4.4K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.4K
Whole Body Regeneration01:33

Whole Body Regeneration

3.6K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.6K
Mechanical Systems01:22

Mechanical Systems

357
Mechanical systems are analogous to to electrical networks where springs and masses play similar roles to inductors and capacitors, respectively. A viscous damper in mechanical systems functions similarly to a resistor in electrical networks, dissipating energy. The forces acting on a mass in such systems include an applied force in the direction of motion, counteracted by forces from the spring, a viscous damper, and the mass's acceleration. This interplay of forces is mathematically...
357
Open and closed-loop control systems01:17

Open and closed-loop control systems

1.2K
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
1.2K
Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

5.1K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
5.1K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.2K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic limits on classical information processing by biological cells.

Bio Systems·2021
Same author

Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control and observational cohort study.

The Lancet. Microbe·2021
Same author

Favorable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases.

Med (New York, N.Y.)·2021
Same author

Morphology changes induced by intercellular gap junction blocking: A reaction-diffusion mechanism.

Bio Systems·2021
Same author

Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook.

Cold Spring Harbor perspectives in biology·2021
Same author

A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies.

Frontiers in pediatrics·2021

Related Experiment Video

Updated: Oct 21, 2025

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

13.3K

A Comprehensive Conceptual and Computational Dynamics Framework for Autonomous Regeneration Systems.

Tran Nguyen Minh-Thai1,2, Sandhya Samarasinghe3, Michael Levin4

  • 1Lincoln University, Complex Systems, Big Data and Informatics Initiative (CSBII).

Artificial Life
|September 2, 2021
PubMed
Summary
This summary is machine-generated.

This study presents a new framework for understanding biological regeneration, inspired by planarian worms. It proposes algorithms for cell cooperation to achieve accurate regeneration and self-repair in engineered systems.

Keywords:
Biological regenerationalgorithms of regenerationcomputational tissues and stem cellsconceptual frameworkneural networksplanariaself-repair agentssynthetic biology

More Related Videos

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.4K
Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
08:25

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

Published on: September 23, 2015

9.2K

Related Experiment Videos

Last Updated: Oct 21, 2025

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

13.3K
Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.4K
Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
08:25

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays

Published on: September 23, 2015

9.2K

Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Synthetic Biology
  • Computational Biology
  • Bio-inspired Computing

Background:

  • Biological organisms exhibit remarkable regenerative capabilities, yet the algorithms governing cell cooperation for consistent morphogenetic outcomes remain incompletely understood.
  • Existing research highlights the need for conceptual frameworks to advance regeneration studies, inform regenerative medicine, and guide synthetic biology applications.
  • Planarian regeneration, known for its robustness and 'immortality,' serves as a key model for understanding complex regenerative processes.

Purpose of the Study:

  • To propose a novel, generic conceptual framework for understanding how cell collectives internally represent and build towards a target morphology after damage.
  • To introduce a nature-inspired computing method for self-repair in engineering and robotics, derived from biological regeneration principles.
  • To hypothesize efficient mechanisms and algorithms for complete and accurate regeneration in a simplified in silico organism, minimizing complexity.

Main Methods:

  • Development of a two-level organizational framework: Level 1 for individual tissue self-repair and Level 2 for organism-wide regeneration coordination.
  • Modeling of in silico tissues (head, body, tail) with stem cells communicating via an information field representing the minimum body plan.
  • Simulation of a stem cell network coordinating regeneration, incorporating collective decision-making and feedback control mechanisms for self-repair.

Main Results:

  • Demonstration of a framework capable of achieving complete and accurate regeneration of a simple flatworm-like organism from any damage through local and collective cellular computations.
  • Validation of the framework's robustness in computer simulations, showing successful recovery of the organism after various simulated injuries.
  • The proposed model minimizes computational and algorithmic complexity while achieving full recovery, extending existing biological regeneration models.

Conclusions:

  • The conceptual framework offers a new perspective on the information-processing aspects of biological regeneration, extending current models.
  • The study provides a novel computational method for self-repair applicable to engineering and robotics, inspired by biological systems.
  • This work lays the groundwork for designing more sophisticated living and non-living self-repairing agents by understanding regeneration algorithms.