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Relationship between coronavirus disease 2019 in pregnancy and maternal and fetal outcomes: Retrospective analytical
Zahra Alipour1, Parisa Samadi2, Narges Eskandari1
1Department of Midwifery, School of Nursing and Midwifery, Qom University of Medical Sciences, Qom, Iran.
Insights
Pregnant women with COVID-19 face increased risks of severe maternal and fetal complications, including ICU admission and preterm birth. This study highlights the adverse outcomes associated with coronavirus disease 2019 in pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19) poses global health challenges.
- Limited data exist on COVID-19's impact on pregnant individuals.
- Understanding these effects is crucial for maternal and fetal health management.
Purpose of the Study:
- To investigate the epidemiological and clinical characteristics of COVID-19 in pregnant women.
- To assess the association between COVID-19 infection and adverse maternal and fetal outcomes.
Main Methods:
- Retrospective analytical cohort study.
- Involved pregnant women diagnosed with COVID-19 and a control group.
- Data collected from medical records; logistic regression analysis used.
Main Results:
- Common symptoms included shortness of breath, cough, and fever.
- COVID-19 in pregnancy significantly increased risks for ICU admission, preterm birth, fetal distress, and NICU admission.
- A trend towards increased Cesarean sections was observed.
Conclusions:
- COVID-19 infection during pregnancy is linked to adverse maternal and fetal outcomes.
- These include higher rates of intensive care unit admission, preterm birth, fetal distress, and neonatal intensive care unit admission.
- Findings underscore the importance of protective measures for pregnant women.
Objective:
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has caused many deaths and complications worldwide. However, limited data are available about COVID-19 during pregnancy. This study aimed to assess the epidemiological and clinical features of COVID-19, and the adverse maternal and fetal outcomes.
Design:
This retrospective analytical cohort study was conducted on all pregnant women with confirmed COVID-19 at Nekouei-Hedayati-Forghani Hospital in Qom, Iran from 15 March 2020 to 15 November 2020. For the same period, 165 pregnant women who did not have COVID-19 were selected at random and included in this study. All epidemiological and clinical features were collected from the medical records of the participants. A logistic regression model was used to determine associations between COVID-19 in pregnancy and maternal and fetal outcomes.
Findings:
The most common symptoms reported by pregnant women with COVID-19 were shortness of breath (60.9%), dry cough (59%) and fever (42.9%). After adjustment for potential confounding factors, COVID-19 in pregnancy was associated with a significantly higher risk of admission to the intensive care unit (ICU) [odds ratio (OR) 6.16, 95% confidence interval (CI) 1.23-31], caesarean section (OR 0.45, 95 CI 0.25-1.03), preterm birth (OR 3.01, 95% CI 1.4-6.54), fetal distress (OR 5.7, 95% CI 2.13-15.59) and admission to the neonatal intensive care unit (NICU) (OR 3.04, 95% CI 1.21-7.70).
Key Conclusions:
COVID-19 is associated with adverse maternal and fetal outcomes, including ICU admission, caesarean section, fetal distress, preterm birth and NICU admission.
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