Related Experiment Video
Updated: Oct 21, 2025
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
Associations Between ADC Texture Analysis and Tumor Infiltrating Lymphocytes in Brain Metastasis - A Preliminary
Hans-Jonas Meyer1, Anne-Kathrin Hohn2, Gordian Prasse3
1Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany; Hans-jonas.meyer@medizin.uni-leipzig.de.
Background/Aim:
Tumor infiltrating lymphocytes (TILs) are an important prognostic factor in brain metastasis (BM). This study elucidated associations between apparent diffusion coefficient (ADC) texture analysis and TIL in BM.
Patients And Methods:
Eleven patients with BM were retrospectively included into the study. TIL levels were analyzed with Leucocyte-common antigen staining. Clinical routine magnetic resonance imaging was used to calculate the texture features.
Results:
ADC GrayLevelNonUniformity correlated with TILs of the stromal compartment (r=0.67, p=0.02). ADC HighGrayLevelRunEmphasis and ADC Coarseness showed associations with TILs of the tumoral compartment (r=-0.60, p=0.04 and r=0.68, p=0.02, respectively).
Conclusion:
ADC texture features correlated with TIL levels in BM. ADC texture features could aid in reflecting the complex tumor-micromilieu in a non-invasive manner.
More Related Videos
05:02Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells
Published on: February 4, 2021
06:05Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
Published on: June 2, 2023