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Inhibitor potency and assay conditions: A case study on SARS-CoV-2 main protease

Mira A M Behnam1, Christian D Klein1

  • 1Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany mira.behnam@uni-heidelberg.de c.klein@uni-heidelberg.de.

Proceedings of the National Academy of Sciences of the United States of America
|September 3, 2021
PubMed
Abstract

No abstract available in PubMed .

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Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.

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