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Related Experiment Videos

High-resolution fast-tomography brain-imaging beamline at the Taiwan Photon Source.

Hsiang Hsin Chen1, Shun Min Yang1, Kai En Yang1

  • 1Institute of Physics, Academia Sinica, 128 Academia Road Sec. 2, Taipei 11529, Taiwan.

Journal of Synchrotron Radiation
|September 3, 2021
PubMed
Summary

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The new Brain Imaging Beamline offers fast 3D synchrotron imaging for brain mapping. Solutions to X-ray damage enable high-throughput, high-resolution scans crucial for research.

Area of Science:

  • Synchrotron radiation science
  • Biomedical imaging
  • Materials science

Background:

  • The Taiwan Photon Source (TPS) has introduced a new Brain Imaging Beamline (BIB).
  • The BIB is designed for advanced 3D imaging using synchrotron X-rays.
  • Previous limitations included X-ray induced damage to detection systems.

Purpose of the Study:

  • To commission and open the Brain Imaging Beamline (BIB) for user access.
  • To enable fast 3D imaging with high spatial resolution.
  • To overcome challenges related to X-ray induced damage for improved performance.

Main Methods:

  • Utilizing bright, unmonochromatized synchrotron X-rays.
  • Implementing tailored filters/attenuators to manage X-ray energy.
Keywords:
brain imaginghigh-resolution X-ray imagingmicrotomography

Related Experiment Videos

  • Employing a high-energy cut-off mirror to protect the detection system.

    • Main Results:

    • Achieved fast 3D imaging with ~1 ms exposure times.
    • Reached high spatial resolution of approximately 0.3 µm.
    • Enabled tomography acquisition throughput exceeding 1 mm³ min⁻¹.

    Conclusions:

    • The Brain Imaging Beamline (BIB) at TPS is now operational for users.
    • Effective mitigation of X-ray induced damage was achieved.
    • The beamline's performance is critical for large-animal brain mapping research.