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Ocular direct current stimulation affects retinal ganglion cells.

Maren-Christina Blum¹, Alexander Hunold², Benjamin Solf²

¹Institute for Biomedical Engineering and Informatics, Technische Universität Ilmenau, Ilmenau, Germany. maren.blum@tu-ilmenau.de.

Scientific Reports

|September 3, 2021

Summary

Ocular current stimulation (oCS) shows promise for treating neurodegenerative eye diseases. Cathodal stimulation significantly increased retinal ganglion cell activity, suggesting a potential therapeutic effect.

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Area of Science:

Ophthalmology
Neuroscience
Biomedical Engineering

Background:

Ocular current stimulation (oCS) demonstrates potential for treating neurodegenerative ocular diseases by positively affecting retinal nerve cells.
Previous studies noted a polarity-independent reduction in P50 amplitude during oCS, but a polarity-dependent trend on the photopic negative response (PhNR) wave.

Purpose of the Study:

To investigate the direct effects of oCS on cumulative retinal ganglion cell activity.
To assess the impact of cathodal, anodal, and sham oCS on the PhNR wave of the full-field electroretinogram (ffERG).

Main Methods:

Utilized a full-field electroretinogram (ffERG) with adjusted parameters for standardized PhNR wave measurement.
Administered simultaneous ocular current stimulation (oCS) with cathodal, anodal, and sham conditions.
Employed repeated-measures ANOVA to analyze differences in PhNR amplitude between groups.

Main Results:

Cathodal oCS significantly increased PhNR amplitude compared to pre-stimulation levels (p=0.006).
Anodal and sham stimulation showed no significant effect on PhNR amplitude.
Repeated-measures ANOVA revealed significant differences in PhNR amplitude between cathodal and anodal groups (p=0.002) and between cathodal and sham groups (p=0.011).

Conclusions:

Cathodal oCS specifically enhances retinal ganglion cell activity, as measured by the PhNR wave.
This finding supports the potential of cathodal oCS as a targeted therapy for conditions affecting retinal ganglion cells.
Further research into oCS parameters and applications for neurodegenerative ocular diseases is warranted.