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Study on the correlation between Left Ventricular Hypertrophy and Coronary Artery disease in the very elderly

Jian-Hua Sun1, Xiao-Kun Liu2, Qi Zhang3

  • 1Jian-hua Sun, Department of Cardiology, Tangshan Workers' Hospital, Tangshan, Hebei, P.R. China.

Pakistan Journal of Medical Sciences
|September 3, 2021
PubMed

Insights

Left ventricular hypertrophy (LVH) is an independent risk factor for coronary artery stenosis and calcification in hypertensive patients over 80. However, LVH did not correlate with the degree of coronary stenosis in this elderly population.

Area of Science:

  • Cardiology
  • Geriatric Medicine
  • Vascular Disease

Background:

  • Hypertension is a prevalent condition in the elderly.
  • Left ventricular hypertrophy (LVH) is a common cardiac adaptation to hypertension.
  • The impact of LVH on coronary artery disease (CAD) in very elderly individuals requires further investigation.

Purpose of the Study:

  • To examine the association between left ventricular hypertrophy (LVH) and coronary artery disease (CAD) in hypertensive patients aged over 80.
  • To identify risk factors contributing to CAD severity in this specific demographic.

Main Methods:

  • A cohort of 120 hypertensive patients over 80 years old was divided into LVH and non-LVH groups.
  • Cardiac color Doppler ultrasound, 24-hour dynamic ECG, and coronary angiography/CTA were performed.
  • Statistical analysis compared clinical data, number of diseased vessels, stenosis degree, and vascular calcification.

Main Results:

  • Significant differences in diseased vessels, stenosis degree, and calcification were observed between groups (P<0.05).
  • LVH, diabetes history, and 2hPG were independent risk factors for three-vessel disease.
  • LVH, FPG, and alcohol intake were independent risk factors for diffuse lesions, with no significant correlation to stenosis degree.

Conclusions:

  • Left ventricular hypertrophy (LVH) is an independent risk factor for coronary artery stenosis and calcification in hypertensive patients over 80.
  • LVH's correlation with the degree of coronary stenosis in this population was not statistically significant.
Abstract

Keywords:
Coronary heart diseaseLeft ventricular hypertrophyVery elderly

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