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Updated: Oct 21, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

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LncRNA-PANDAR regulates the progression of thyroid carcinoma by targeting miR-637/KLK4

Yi Qing1, Qian Li2, Ling-Yan Zhao3

  • 1Department of Oncology, Affiliated Hospital of Chengdu University, Chengdu 610081, People's Republic of China.

Journal of Cancer
|September 3, 2021
PubMed

Insights

Promoter Region of CDKN 1A antisense DNA damage-activated RNA (PANDAR) promotes thyroid cancer growth and metastasis by suppressing miR-637 and upregulating KLK4. PANDAR represents a potential therapeutic target for thyroid gland carcinoma.

Area of Science:

  • Molecular Oncology
  • RNA Biology
  • Endocrinology

Background:

  • Thyroid gland carcinoma (TC) is a common endocrine malignancy.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in tumorigenesis.
  • Understanding lncRNA regulation in TC is crucial for developing new therapies.

Purpose of the Study:

  • To investigate the molecular mechanisms of lncRNAs in thyroid gland carcinoma progression.
  • To identify specific lncRNAs involved in TC growth and metastasis.
  • To explore PANDAR as a potential therapeutic target in TC.

Main Methods:

  • Identification and analysis of lncRNAs in thyroid gland carcinoma.
  • Investigating the correlation between PANDAR, miR-637, and KLK4 expression.
  • Functional assays to assess the impact of PANDAR and miR-637 on TC cells.
  • In vivo studies using nude mice to evaluate PANDAR's role in cancer progression.

Main Results:

  • PANDAR expression is positively correlated with thyroid gland carcinoma risk.
  • PANDAR promotes TC cell proliferation and metastasis by suppressing miR-637.
  • miR-637 targets KLK4, and its suppression by PANDAR leads to increased KLK4 expression.
  • KLK4 inhibits cell progression in TC.
  • Knockdown of PANDAR inhibited tumor growth in vivo.

Conclusions:

  • PANDAR promotes thyroid gland carcinoma invasion and migration by suppressing miR-637 and inducing KLK4.
  • miR-637 acts as a tumor suppressor in TC.
  • PANDAR is a novel therapeutic target for thyroid gland carcinoma treatment.
Keywords:
KLK4LncRNA PANDARMiR-637ProgressionThyroid gland carcinoma

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