Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Cancer Therapies02:49

Cancer Therapies

8.4K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Undifferentiated pleomorphic sarcoma of bone (UPSB) treated in the German-speaking countries. A report of 132 unselected patients from the Cooperative Osteosarcoma Study Group (COSS).

Journal of cancer research and clinical oncology·2026
Same author

Osteosarcoma of the Diaphysis: A Report from the Cooperative Osteosarcoma Study Group (COSS).

Anticancer research·2025
Same author

Teleangiectatic Osteosarcoma Treated by Surgery and Chemotherapy: A Report of 223 Affected Patients From the Cooperative Osteosarcoma Study Group (COSS).

Cancer medicine·2025
Same author

Prognostic factors in patients with relapsed high-grade osteosarcoma: a systematic review.

British journal of cancer·2025
Same author

A European consensus recommendation on the management of delayed methotrexate elimination: supportive measures, leucovorin rescue and glucarpidase treatment.

Journal of cancer research and clinical oncology·2024
Same author

Osteosarcoma as a secondary malignancy following rhabdomyosarcoma: A report of 28 affected patients from the Cooperative Osteosarcoma Study Group (COSS).

Pediatric blood & cancer·2024
Same journal

Telescopic rods vs. non-telescopic rods in the treatment of osteogenesis imperfecta: A systematic review.

Journal of children's orthopaedics·2026
Same journal

Proximal ulnar osteochondroma as a potential risk factor for radial head dislocation: A retrospective analysis.

Journal of children's orthopaedics·2026
Same journal

Guided growth: Current concepts and novel techniques for harnessing a child's growth potential.

Journal of children's orthopaedics·2026
Same journal

Factors associated with open reduction of pediatric type III supracondylar humerus fractures.

Journal of children's orthopaedics·2026
Same journal

Irreducible extremity fractures in pediatric and adolescent rodeo-related trauma: A retrospective case series.

Journal of children's orthopaedics·2026
Same journal

Late-developing acetabular dysplasia following normal infant hip ultrasound in breech and family-history cohorts: A systematic review.

Journal of children's orthopaedics·2026
See all related articles

Related Experiment Video

Updated: Oct 21, 2025

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

9.0K

Bone sarcoma: success through interdisciplinary collaboration.

Stefanie Hecker-Nolting1,2, Ana Maia Ferreira3,2, Stefan S Bielack1,4

  • 1Pädiatrie 5 (Onkologie, Hämatologie, Immunologie), Zentrum für Kinder-, Jugend- und Frauenmedizin, Stuttgart Cancer Center, Klinikum Stuttgart - Olgahospital, Stuttgart, Germany.

Journal of Children'S Orthopaedics
|September 3, 2021
PubMed
Summary
This summary is machine-generated.

Effective treatment for pediatric bone sarcomas like osteosarcoma and Ewing sarcoma requires combining local therapy with chemotherapy. While progress in drug development has been slow, interdisciplinary collaboration is crucial for successful outcomes.

Keywords:
Ewing sarcomachemotherapyinterdisciplinary collaborationosteosarcoma

More Related Videos

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.4K
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.0K

Related Experiment Videos

Last Updated: Oct 21, 2025

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

9.0K
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.4K
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.0K

Area of Science:

  • Pediatric Oncology
  • Skeletal Tumors

Background:

  • Osteosarcoma and Ewing sarcoma are primary malignant bone tumors in children and adolescents.
  • These conditions represent significant challenges in pediatric oncology.

Purpose of the Study:

  • To review the oncologist's perspective on osteosarcoma and Ewing sarcoma.
  • To summarize current treatment strategies for these pediatric bone cancers.

Main Methods:

  • A non-systematic literature review was conducted.
  • Author insights and clinical experience were incorporated.

Main Results:

  • Neither local therapy nor chemotherapy alone is curative for malignant bone sarcomas.
  • The combination of local therapy and chemotherapy is highly effective.
  • Limited progress has been made in identifying new effective drugs, but research into relapsed disease treatments may inform frontline therapies.
  • Palliative care is essential when cure is not achievable.

Conclusions:

  • Successful treatment of pediatric bone sarcomas hinges on close interdisciplinary collaboration.
  • Multidisciplinary teams are vital for optimizing patient care and outcomes.