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Updated: Oct 21, 2025

Vibratome Sectioning Mouse Retina to Prepare Photoreceptor Cultures
Published on: December 22, 2014
Recent advances on visual cycle protein research and progress on clinical translation
Xin Yee Ooi1, Rujman Khan1,2, Anjalee Choudhury1
1Department of Molecular Science, University of Texas Rio Grande Valley School of Medicine, Edinburg, Texas, 78541, USA.
Abstract:
Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP. In addition, we emphasize the progress of clinical translation of other visual cycle protein research, including the breakthrough of FDA-approved gene therapy for Leber's congenital amaurosis, and additional gene therapies at different stages of clinical trials for various retinal diseases such as retinitis pigmentosa, diabetic retinopathy, and Stargardt's disease.
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