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Tracheal chondrosarcoma: A case report, systematic review, and pooled analysis.
Mitchell Heuermann1, Simon Bekker2, Thomas Czeczok3
1Department of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA.
Cancer Reports (Hoboken, N.J.)
|September 3, 2021
Summary
Complete surgical resection is key for treating tracheal chondrosarcoma. Open surgery with negative margins offers the best chance for disease control, while advanced age is linked to recurrence.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Tracheal chondrosarcoma is a rare cancer with no established treatment guidelines.
- Evidence is primarily based on limited case reports.
Observation:
- A review of 35 tracheal chondrosarcoma cases since 1959 was conducted.
- Advanced age was significantly associated with disease recurrence (p=0.003).
- Open surgical resection was the primary treatment for 77% of patients.
Findings:
- Open surgical approach and negative margins were significantly linked to being disease-free (p=0.001 and p<0.001).
- Adjuvant radiotherapy was used for patients unfit for surgery or with recurrent disease.
- Tumor characteristics like size or calcification did not correlate with recurrence.
Implications:
- Adequate surgical resection is crucial for managing non-metastatic tracheal chondrosarcoma.
- Chemotherapy and adjuvant radiotherapy have limited roles in treatment.
- Achieving negative surgical margins is vital for oncologic control.
