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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...

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Related Experiment Video

Updated: Jun 22, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Tracheal chondrosarcoma: A case report, systematic review, and pooled analysis.

Mitchell Heuermann1, Simon Bekker2, Thomas Czeczok3

  • 1Department of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, USA.

Cancer Reports (Hoboken, N.J.)
|September 3, 2021
PubMed
Summary

Complete surgical resection is key for treating tracheal chondrosarcoma. Open surgery with negative margins offers the best chance for disease control, while advanced age is linked to recurrence.

Keywords:
chondrosarcomahead and neck sarcomasystematic reviewtracheal cancertracheal chondrosarcoma

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Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Tracheal chondrosarcoma is a rare cancer with no established treatment guidelines.
  • Evidence is primarily based on limited case reports.

Observation:

  • A review of 35 tracheal chondrosarcoma cases since 1959 was conducted.
  • Advanced age was significantly associated with disease recurrence (p=0.003).
  • Open surgical resection was the primary treatment for 77% of patients.

Findings:

  • Open surgical approach and negative margins were significantly linked to being disease-free (p=0.001 and p<0.001).
  • Adjuvant radiotherapy was used for patients unfit for surgery or with recurrent disease.
  • Tumor characteristics like size or calcification did not correlate with recurrence.

Implications:

  • Adequate surgical resection is crucial for managing non-metastatic tracheal chondrosarcoma.
  • Chemotherapy and adjuvant radiotherapy have limited roles in treatment.
  • Achieving negative surgical margins is vital for oncologic control.