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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Oct 21, 2025

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Lethal giant basal cell carcinoma.

Roger W Byard^1,2, Stephen Wills¹, John D Gilbert¹

¹Forensic Science SA, The University of Adelaide, Australia.

Medicine, Science, and the Law

|September 3, 2021

Summary

This summary is machine-generated.

Basal cell carcinomas are rare but can be fatal if left untreated. Two cases illustrate lethal outcomes from neglected, ulcerated tumors, highlighting the need for prompt medical attention.

Keywords:

Diogenes syndrome Giant basal cell carcinoma death forensic sepsis

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Area of Science:

Oncology
Dermatology

Background:

Basal cell carcinoma (BCC) is the most common skin cancer in Caucasians.
BCC typically has an excellent prognosis with appropriate treatment and rarely metastasizes.

Observation:

Two cases of fatal outcomes from untreated basal cell carcinomas are presented.
Case 1: A 61-year-old man died from hypothermia and sepsis complicating an extensively ulcerated facial BCC.
Case 2: A 60-year-old man died from sepsis, inanition, and pulmonary thromboembolism complicating a deeply ulcerated lumbar BCC.

Findings:

Untreated giant basal cell carcinomas can lead to complex, lethal pathophysiological mechanisms.
Complications include severe infection, sepsis, inanition, and thromboembolism.

Implications:

These cases underscore the importance of timely diagnosis and treatment for basal cell carcinoma.
The possibility of Diogenes syndrome should be considered in patients with neglected, advanced skin cancers.