Related Experiment Video

Updated: Oct 21, 2025

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

2.0K

Skin Involvement in Paediatric Patients with Type 1 Diabetes

Stefano Passanisi1, Giuseppina Salzano1, Fortunato Lombardo1

  • 1Department of Human Pathology in Adult and Developmental Age, University of Messina, Messina, Italy.

Current Diabetes Reviews
|September 3, 2021
PubMed

Insights

Skin issues are common in children with type 1 diabetes, including lipodystrophies and dermatitis. Early recognition and management of these skin disorders are crucial for patient care.

Area of Science:

  • Pediatric Endocrinology
  • Dermatology
  • Metabolic Disorders

Background:

  • Skin involvement is frequently overlooked in managing pediatric patients with type 1 diabetes.
  • Dermatological side effects are common in children and adolescents with diabetes.

Purpose of the Study:

  • To highlight the significance of skin assessment in pediatric type 1 diabetes management.
  • To review common and associated skin disorders in this population.

Main Methods:

  • Comprehensive literature search of the PubMed database.
  • Keywords used: "children," "pediatric/paediatric patients," "skin," "skin disorders," "type 1 diabetes."

Main Results:

  • Common skin reactions include insulin-induced lipodystrophies and allergic contact dermatitis from devices.
  • Diabetes-associated skin diseases like necrobiosis lipoidica, granuloma annulare, vitiligo, and bullosis diabeticorum can be present.
  • Non-invasive assessment of skin advanced glycation end-products may predict chronic complications.

Conclusions:

  • Pediatric diabetes specialists must prioritize skin evaluation for early detection and treatment of skin disorders.
  • Monitoring skin health is integral to comprehensive care for pediatric type 1 diabetes patients.
  • Advanced glycation end-product measurement offers potential for early risk assessment of complications.

Keywords:
Advanced glycation end-productscontact dermatitisgranuloma annulareinsulinlipoatrophylipohypertrophynecrobiosis lipoidicaskin autofluorescence

More Related Videos

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

16.9K
High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network09:54

High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network

Published on: January 29, 2018

11.2K

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.8K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.5K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.3K
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
314
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.1K