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COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases

Areti Papadopoulou1,2, Hanan Musa1, Mathura Sivaganesan3

  • 1William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Plos One
|September 3, 2021
PubMed

Insights

Genetically determined COVID-19 susceptibility is linked to a higher risk of blood clots in the legs and lungs. This finding helps identify individuals at increased risk for adverse COVID-19 outcomes and long-term effects.

Area of Science:

  • Genetics and Epidemiology
  • Infectious Disease Research
  • Cardiovascular Health

Background:

  • Comorbidities like diabetes and vascular disease increase COVID-19 severity risk.
  • Genome-wide association studies (GWAS) suggest genetic links to COVID-19 susceptibility and severity.
  • The genetic basis of these COVID-19 associations requires further investigation.

Purpose of the Study:

  • To investigate the role of genetically determined COVID-19 susceptibility in disease-related outcomes.
  • To identify traits and diseases associated with COVID-19 susceptibility and severity using a Phenome-Wide Association (PheWAS) approach.
  • To evaluate COVID-19 risk using a predictive risk score.

Main Methods:

  • Utilized phenotypic data from up to 400,000 UK Biobank individuals.
  • Included Hospital Episode Statistics and General Practice data for comprehensive analysis.
  • Employed a Phenome-Wide Association (PheWAS) study design.

Main Results:

  • Identified associations between genetically determined COVID-19 susceptibility/severity and various traits.
  • COVID-19 risk showed association with increased risk for phlebitis and thrombophlebitis (OR = 1.11).
  • Significant signals linked COVID-19 susceptibility to blood clots in the leg (OR = 1.1) and lung (OR = 1.12).

Conclusions:

  • Genetically determined COVID-19 is significantly associated with an increased risk of blood clots in the legs and lungs.
  • These associations aid in identifying and stratifying individuals at higher risk for adverse COVID-19 outcomes.
  • Findings contribute to understanding long-term effects and risk stratification for COVID-19 patients.

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