Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proteomics01:33

Proteomics

8.6K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
8.6K
Protein Networks02:26

Protein Networks

4.2K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phosphoproteomic approach for agonist-specific signaling in mouse brains: mTOR pathway is involved in κ opioid aversion.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2018
Same author

The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications.

Clinical cancer research : an official journal of the American Association for Cancer Research·2018
Same author

In-depth proteomic analyses of <i>Haliotis laevigata</i> (greenlip abalone) nacre and prismatic organic shell matrix.

Proteome science·2018
Same author

Multi-Protein Complexes Studied by Mass Spectrometry.

TheScientificWorldJournal·2018
Same author

In vivo brain GPCR signaling elucidated by phosphoproteomics.

Science (New York, N.Y.)·2018
Same author

The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia.

Circulation research·2018

Related Experiment Video

Updated: Oct 21, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

12.2K

SnapShot: Clinical proteomics.

Yi Zhu1, Ruedi Aebersold2, Matthias Mann3

  • 1Westlake Laboratory of Life Sciences and Biomedicine, Westlake University, Hangzhou, China.

Cell
|September 3, 2021
PubMed
Summary
This summary is machine-generated.

Quantitative proteomic analysis of clinical specimens provides key insights into health and disease. This overview covers common and emerging mass spectrometry (MS) workflows for analyzing protein composition.

More Related Videos

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
14:51

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Published on: November 13, 2021

5.6K
A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
09:52

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

863

Related Experiment Videos

Last Updated: Oct 21, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

12.2K
Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
14:51

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Published on: November 13, 2021

5.6K
A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
09:52

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

863

Area of Science:

  • Biochemistry
  • Analytical Chemistry
  • Clinical Proteomics

Background:

  • Quantitative proteomic analysis of clinical specimens is crucial for understanding physiological and pathological states.
  • Numerous methodologies exist, necessitating a summary of current approaches.

Purpose of the Study:

  • To provide an overview of common and emerging mass spectrometry (MS)-based workflows for quantitative proteomic analysis.
  • To highlight the importance of proteomic analysis in clinical settings.

Main Methods:

  • Mass spectrometry (MS)-based workflows are the primary focus.
  • Discussion includes both established and novel MS techniques.

Main Results:

  • The abstract indicates a summary of MS-based workflows is presented.
  • Specific results are not detailed due to the overview nature and space limitations.

Conclusions:

  • Quantitative proteomic analysis using MS is a valuable tool for clinical research.
  • The field continues to evolve with emerging MS methodologies.