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Mini-review: The suspected non-Alzheimer's disease pathophysiology
Liara Rizzi1, Marcio L F Balthazar1
1Department of Neurology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Abstract:
Suspected non-Alzheimer's disease pathophysiology (SNAP) is a biomarker-based concept that underlying etiology has not been completely understood. Refers to a group of individuals that are negative for amyloid biomarkers and positive for p-Tau and/or neurodegeneration. SNAP causes great research interest because it is not clear if they have a different biological basis from Alzheimer's disease (AD), or are in an early stage of AD itself. The pathological processes behind SNAP need to be clarified. This mini-review aims to summarize the main characteristics of SNAP, besides reporting challenges and promising biomarkers related to the concept.
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