Related Experiment Video
Updated: Oct 21, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Forecasting COVID-19 infections with the semi-unrestricted Generalized Growth Model
Pablo Pincheira-Brown1, Andrea Bentancor2
1Business School, Universidad Adolfo Ibáñez, Chile.
Abstract:
Recently, the Generalized Growth Model (GGM) has played a prominent role as an effective tool to predict the spread of pandemics exhibiting subexponential growth. A key feature of this model is a damping parameter p that is bounded to the [0,1] interval. By allowing this parameter to take negative values, we show that the GGM can also be useful to predict the spread of COVID-19 in countries that are at middle stages of the pandemic. Using both in-sample and out-of-sample evaluations, we show that a semi-unrestricted version of the model outperforms the traditional GGM in a number of countries when predicting the number of infected people at short horizons. Reductions in Root Mean Squared Prediction Errors (RMSPE) are shown to be substantial. Our results indicate that our semi-unrestricted version of the GGM should be added to the traditional set of phenomenological models used to generate forecasts during early to middle stages of epidemic outbreaks.
Related Concept Videos
Steps in Outbreak Investigation
Parametric Survival Analysis: Weibull and Exponential Methods
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
Residuals and Least-Squares Property
If the observed data point lies above the line, the residual is positive, and the line underestimates the actual data value for y. If the observed data point lies below the line, the residual is negative, and the line overestimates the actual data value for y.
The process of fitting the best-fit...
Statistical Methods for Analyzing Epidemiological Data
Estimating Population Mean with Unknown Standard Deviation
William S. Gosset (1876–1937) of the...
Prediction Intervals
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.

