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Childhood-onset Systemic Lupus Erythematosus: Patients features and their transition into adulthood

Paula Valenzuela1, Mabel Ladino2, Nelson Vargas3

  • 1Hospital Félix Bulnes, Santiago, Chile.

Andes Pediatrica : Revista Chilena De Pediatria
|September 3, 2021
PubMed

Insights

This study details childhood-onset Systemic Lupus Erythematosus (SLE) in Chile, highlighting common clinical features like arthritis and renal involvement. It also examines patient outcomes and the transition from pediatric to adult care.

Area of Science:

  • Pediatric Rheumatology
  • Autoimmune Diseases
  • Clinical Epidemiology

Background:

  • Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with diagnostic challenges.
  • Limited data exists on pediatric SLE in South America.
  • Understanding childhood-onset SLE is crucial for effective management and transition to adulthood.

Purpose of the Study:

  • To characterize clinical and laboratory features of childhood-onset SLE in Chilean patients.
  • To describe the disease course, treatment, and complications.
  • To analyze the transition of these patients from pediatric to adult healthcare.

Main Methods:

  • Retrospective study of 31 pediatric SLE patients diagnosed between 2001-2017 in Santiago, Chile.
  • Data collected included demographics, clinical manifestations, laboratory findings, treatments, and outcomes.
  • Severe SLE was defined by renal or central nervous system involvement.

Main Results:

  • The most common symptoms were arthritis (87%), skin lesions (58%), and renal involvement (58%).
  • Key laboratory findings included positive antinuclear antibodies (100%) and anti-dsDNA antibodies (74%).
  • No mortality was observed; 97% had satisfactory pediatric check-ups, with 59% satisfactory adult check-ups.

Conclusions:

  • This study provides valuable insights into pediatric SLE in Chile, aligning with international findings.
  • It emphasizes the importance of managing the transition from pediatric to adult care for SLE patients.
  • The findings contribute to the limited literature on South American pediatric SLE populations.
Abstract

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