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Updated: Oct 21, 2025

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
[Performance of formulas for the evaluation of 24-hour urine collections using urine creatinine excretion]
Jorge Vega1, Juan Pablo Huidobro E1, Francisco J Guarda2
1Unidad de Nefrología, Hospital Naval Almirante Nef., Viña del Mar, Chile.
Abstract:
Creatinine excretion is widely used as a method to evaluate the adequacy of urine collection in different clinical settings. Many factors influence its elimination, such as protein intake, exercise, muscle mass, age, and sex, among many others. As 24-hour urine collections can be cumbersome, several equations have been developed to aid clinicians to correctly interpret results derived from them. In this review article, we report the factors that can modify creatinine excretion and we evaluate the accuracy of different published equations to estimate 24-hour urine creatinine excretion.
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