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Updated: Oct 21, 2025
Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
[Vitamin D levels in patients with inflammatory bowel disease]
Gloria Horta1, Sebastián Soto2, Gonzalo Labarca2
1Complejo Asistencial Dr. Víctor Ríos Ruiz, Los Ángeles, Chile.
Background:
Inflammatory Bowell Diseases (IBD), either ulcerative colitis (UC) or Chron's disease (CD) are commonly associated with intestinal malabsorption, and insufficient levels 1-25 hydroxycholecalciferol (vitamin D). These insufficient levels could be linked with an increased risk of clinical disease activity.
Aim:
To report vitamin D levels in patients with IBD living in Southern Chile and their possible association with clinical disease activity.
Material And Methods:
A prospective, observational study in outpatients with IBD living in Los Angeles, Chile. Demographic data and clinical activity using clinical scores were recorded. Vitamin D levels and fecal calprotectin were measured.
Results:
We studied 44 patients, 32 (73%) with UC and 12 (27%) with CD. The median age at diagnosis was 33 years old. Forty-one (93%) had mild-inactive disease and 3 (7%) a moderate disease. Mean vitamin D levels were 15.2 ± 7.1 ng/ml. Twenty five percent of patients had sufficient levels (> 20 ng/ml), 35% insufficient levels and 40% poor levels. No association between these levels and disease activity was found.
Conclusions:
These patients with IBD had a high frequency of hypovitaminosis D.
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