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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Disorders of Hemostasis01:24

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Disorders of Erythrocytes01:27

Disorders of Erythrocytes

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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
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Updated: Oct 21, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
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KSHV/HHV8-mediated hematologic diseases.

Ethel Cesarman1, Amy Chadburn1, Paul G Rubinstein2,3

  • 1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.

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Summary
This summary is machine-generated.

Kaposi sarcoma (KS) herpesvirus (KSHV) causes KS and related B-cell cancers like primary effusion lymphoma (PEL). Understanding KSHV

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Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Kaposi sarcoma (KS) herpesvirus (KSHV), or human herpesvirus 8, is linked to KS and various lymphoproliferative disorders.
  • KSHV, like Epstein-Barr virus (EBV), infects B cells, particularly in immunocompromised individuals, and can drive abnormal lymphoid proliferations.
  • KSHV-associated diseases such as primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD) share overlapping features but have distinct viral and cellular characteristics.

Purpose of the Study:

  • To elucidate the pathogenic mechanisms of KSHV in lymphoproliferative disorders.
  • To differentiate between KSHV-MCD and PEL/EC-PEL based on viral associations and gene expression.
  • To highlight the need for improved, targeted therapies for KSHV-associated malignancies.

Main Methods:

  • Comparative analysis of KSHV-associated diseases, including PEL/EC-PEL and KSHV-MCD.
  • Investigation of viral gene expression patterns and their role in cellular transformation.
  • Phenotypic and genotypic characterization of infected B cells in different KSHV-associated conditions.

Main Results:

  • KSHV transforms B cells, contributing to lymphoproliferative disorders through viral gene expression affecting proliferation and survival.
  • Distinct differences exist between KSHV-MCD and PEL/EC-PEL regarding viral associations, gene expression, and B-cell differentiation.
  • Co-occurrence of KSHV and EBV in PEL/EC-PEL highlights shared B-cell transformation pathways.

Conclusions:

  • Despite treatment advances, mortality for KSHV-associated diseases remains high.
  • A deeper understanding of KSHV biology and disease manifestations is crucial for developing better therapeutic strategies.
  • Targeted interventions based on improved knowledge of KSHV pathogenesis offer promise for enhanced patient outcomes.