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Glucagon-Like Peptide-1 Receptor Agonists and Brain Vascular Function
Edin Begic1, Mirsada Causevic2
1Department of Cardiology, General Hospital "Prim.Dr. Abdulah Nakas", Sarajevo, Bosnia and Herzegovina; Department of Pharmacology, Sarajevo Medical School, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina.
Glucagon-like peptide 1 (GLP-1) receptor agonists show cardiorenal benefits beyond glucose lowering. These agents aid in preventing atherosclerotic changes and preserving brain vascular function, suggesting potential in neurodegenerative disease treatment.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Neuroscience
Background:
- Cardiovascular medicine aims to prevent events and regress atherosclerosis.
- Endothelial dysfunction causes arterial thrombosis by disrupting vascular hemostasis.
- Glucagon-like peptide 1 (GLP-1) receptor agonists, initially for glucose control, now offer cardiorenal benefits.
Purpose of the Study:
- To review the benefits of GLP-1 receptor agonists in preventing atherosclerotic changes.
- To discuss their role in preserving brain vascular function.
- To explore their potential therapeutic use in neurodegenerative diseases.
Main Methods:
- Literature review of studies on GLP-1 receptor agonists.
- Analysis of evidence regarding cardiovascular and cerebrovascular effects.
- Exploration of mechanisms underlying potential neuroprotective roles.
Main Results:
- GLP-1 receptor agonists demonstrate efficacy in mitigating atherosclerosis progression.
- Evidence suggests a positive impact on maintaining brain vascular health.
- Emerging data indicate potential benefits for neurodegenerative conditions.
Conclusions:
- GLP-1 receptor agonists offer significant advantages in cardiovascular prevention and atherosclerosis regression.
- Their beneficial effects extend to cerebrovascular health.
- Further research is warranted to establish their role in treating neurodegenerative diseases.
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