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Related Experiment Video

Updated: Oct 21, 2025

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice
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A Novel Microcontroller-Based System for the Wheel-Running Activity in Mice.

Meina Zhu1, Deepa Kamath Kasaragod1, Kazuya Kikutani2

  • 1Department of Neurobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.

Eneuro
|September 4, 2021
PubMed
Summary

Researchers developed a novel, cost-effective system to monitor mouse wheel-running activity within their home cages. This tool aids in studying circadian rhythms and exercise motivation, crucial for understanding sleep and psychiatric disorders.

Keywords:
circadian rhythmmicrocontrollermouseopen-sourcewheel running

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Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Animal Models

Background:

  • Voluntary wheel-running activity in rodents is a key indicator of circadian rhythm and exercise motivation.
  • Deficits in these behaviors are linked to sleep and psychiatric disorders.
  • Limited space in animal facilities restricts long-term monitoring of wheel-running activity.

Purpose of the Study:

  • To develop a stand-alone system for monitoring mouse wheel-running activity within their home cages.
  • To provide a cost-effective and robust solution for long-term behavioral analysis.

Main Methods:

  • Development of the wheel-running activity acquisition (WRAQ) system, a battery-powered microcontroller-based device.
  • Recording wheel-running activity and illumination data for extended periods (≥30 days).
  • Application of the WRAQ system in an endotoxemia mouse model and utilizing an extended version for online circadian time monitoring.

Main Results:

  • The WRAQ system successfully recorded wheel-running activity and illumination data for over 30 days.
  • The system robustly detected altered wheel-running activity and its recovery in an endotoxemia mouse model.
  • Online monitoring with the extended WRAQ system revealed significant shifts in circadian rhythm activity following SCN-SPZ chemogenetic activation.

Conclusions:

  • The WRAQ system offers a novel, cost-effective solution for analyzing mouse wheel-running activity.
  • This system facilitates long-term behavioral monitoring essential for research into circadian rhythms and related disorders.
  • The WRAQ system enables real-time monitoring and analysis of circadian behaviors, aiding in the study of neural circuit function.