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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

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Published on: August 16, 2018

The relation between parietal GABA concentration and numerical skills.

George Zacharopoulos^1,2, Francesco Sella³, Uzay Emir⁴

¹Department of Experimental Psychology, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK. george.zacharopoulos@psy.ox.ac.uk.

Scientific Reports

|September 4, 2021

Summary

Lower levels of the inhibitory neurotransmitter GABA in the brain

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Area of Science:

Neuroscience
Cognitive Science
Mathematics

Background:

Mathematical advancements rely on individuals with strong numerical skills.
Neurotransmitter roles in numerical cognition are not well understood.
Existing research on brain networks for math is primarily anatomical and functional.

Purpose of the Study:

To investigate the relationship between numerical skills and brain neurotransmitters.
To examine the roles of GABA and glutamate in numerical cognition.

Main Methods:

Utilized 1H magnetic resonance spectroscopy (MRS) in 54 participants.
Measured resting concentrations of GABA and glutamate in specific brain regions.
Assessed numerical skills using a number sequences task.

Main Results:

Found a negative association between GABA concentration in the left intraparietal sulcus (IPS) and performance on a number sequences task.
This relationship was specific to the parietal lobe and the inhibitory neurotransmitter GABA.
Frontoparietal functional connectivity was positively associated with numerical performance, but IPS GABA levels explained performance independently.

Conclusions:

GABA in the left IPS is a significant biological basis for numerical skills.
Highlights the importance of inhibitory neurotransmission in numerical cognition.
Suggests further research into brain inhibition mechanisms and their role in mathematical abilities.